The Role of Fibrinogen on Abortion Incidence in Pregnant Women with Toxoplasmosis

Toxoplasma gondii is the cause of toxoplasmosis. More than 60% world's population infected with T. gondii. The prevalence acute toxoplasmosis in pregnant women 4.8 per 1000 women. risk fetal infection until 13 weeks gestation about 15% and after that increases reaches 72% at 36 gestation. Fibrinogen one most important phase proteins Physiologically, there an increase blood procoagulant levels (include fibrinogen), but anticoagulant decrease during pregnancy performance fibrinolytic system weakens. In this condition, if woman pregnancy, excessive elevation coagulation factors may thromboembolism. known to IFN-γ secretion sheep rat experimental animals, then secrete fibrinogen-like protein 2 (fgl2) which plays a role fibrin deposition thrombosis. Fgl2 transmembrane prothrombinase directly cleaves prothrombin thrombin. activity was observed abortion. Overall, gets stronger However, inflammatory process due results prothrombic state situation associated increased fibrinogen levels. Increased further inflammation. Excessive thromboembolism causes placental infarct